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​Exploring the Chemistry and Biology of Nucleic Acids​

PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
​Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.

​What our lab studies:

- G-quadruplex Structure and Function

- RNA Biology and Gene Regulation

- Aptamer and NGS Development


Funding sources:
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​Recent publications:
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Zhao, H. & Kwok, C.K. Bringing distant DNA together. Nature Chem. Bio. 17, 125-126 (2021). 

Mou, X. & Kwok, C.K. Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction. Biochem. Biophys. Res.Commun. 533, 1135-1141 (2020).

Umar, M.I. & Kwok, C.K.
Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer. Nucleic Acids Res. 48, 10125-10141 (2020).

Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol 21, 226 (2020).

Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics, bbaa114 (2020).


Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology 17, 903-917 (2020).

Chan, C. Y., & Kwok, C. K. Specific Binding of a D‐RNA G‐Quadruplex Structure with an L‐RNA Aptamer. Angew. Chem. Int. Ed. 59, 5293 –5297 (2020). 

​Recent lab news:
​

Jan 2021: New paper published in Nature Chemical Biology! Congratulations to Haizhou!

Jan 2021: A big welcome to Beatrice as a new UG member of Kwok Lab!

Dec 2020: Welcome Andrea as a new postdoc (part time) in Kwok Lab!


Oct 2020: Our new paper is now online in Biochemical and Biophysical Research Communications! Congratulations to Xi! 

Sep 2020: Paper published in Nucleic Acids Research! Congrats to Mubarak!

Sep 2020: Happy graduation to Mubarak on the PhD programme! Congratulations! 

Sep 2020: 
Our new paper is now online in Genome Biol! Congratulations to Mubarak and Jieyu!

July 2020: A big welcome to Caroline as a new UG member of Kwok Lab!

June 2020: Our new paper is now published in Briefings in Bioinformatics! Congratulations to Danyang!

April 2020:
Paper published in RNA Biology! Congratulations to Kaixin! More coming soon!

Jan 2020: Our new paper is now published in Angew. Chem. Int. Ed.. Congrats to Jamie!

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