Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
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Recent publications: Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol 21, 226 (2020). Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics DOI: https://doi.org/10.1093/bib/bbaa114 (2020). Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology 17, 903-917 (2020). Chan, C. Y., & Kwok, C. K. Specific Binding of a D‐RNA G‐Quadruplex Structure with an L‐RNA Aptamer. Angew. Chem. Int. Ed. 59, 5293 –5297 (2020). Shao, X., Zhang, W., Umar, M. I., Wong, H. Y., Seng, Z., Xie, Y., Zhang, Y., Yang, L., Kwok, C. K. & Deng, X. RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria. mBio 11, 1 (2020). Ji, D., Li, Z., & Kwok, C.K. Rational design and development of a universal baby spinach-based sensing platform for the detection of biomolecules. Analyst 144, 7173 - 7177 (2019). Lyu, K., Chen, S. B., Chan, C.-Y., Tan, J. H., & Kwok, C.K. Structural analysis and cellular visualization of APP RNA G-quadruplex. Chemical Science. 10, 11095 - 11102 (2019). Ji, D., Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Analytical Methods 11, 4808 - 4813 (2019). |
Recent lab news: Sep 2020: Our new paper is now online in Genome Biol! Congratulations to Mubarak and Jieyu! July 2020: A big welcome to Caroline as a new UG member of Kwok Lab! June 2020: Our new paper is now published in Briefings in Bioinformatics! Congratulations to Danyang! April 2020: Paper published in RNA Biology! Congratulations to Kaixin! More coming soon! Jan 2020: Our new paper is now published in Angew. Chem. Int. Ed.. Congrats to Jamie! Jan 2020: Dr. Kwok was awarded the 2019 CityU President Award and 2019 Croucher Innovation Award! Congratulations! Jan 2020: Our new paper is now published in mBio! Congratulations to Mubarak and Phoebe! Nov 2019: Paper published in Analyst! Congrats to Danyang! Oct 2019: Our new paper is now online in Chemical Science! Congratulations to Kaixin and Jamie! Sept 2019: Congratulations to Danyang and Xi on their new paper in Analytical Methods! Sept 2019: Kaixin was awarded one of the best poster awards in the G4 conference. Congratulations! |