Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
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Recent publications: Ji, D., Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Analytical Methods 11, 4808 - 4813 (2019). Umar, M.I.; Ji, D.; Chan, C.-Y.; Kwok, C.K. G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications. Molecules 24, 2416 (2019). Yeung, P.Y., Zhao, J., Chow, E.Y.C., Mou, X., Hong, H.Q., Chen, L.L., Chan, T.F., Kwok, C.K. Systematic evaluation and optimization of the experimental steps in RNA G-quadruplex structure sequencing. Sci. Rep. 9, 8091 (2019). Zhao, J., Qian, X., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Mapping In Vivo RNA Structures and Interactions. Trends Biochem. Sci. 44, 555-556 (2019). Chan, C.-Y., Umar, M.I., Kwok, C.K. Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures. Chem Comm. 55, 2616 - 2619 (2019). Qian, X., Zhao, J., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Revealing LncRNA Structures and Interactions by Sequencing-Based Approaches. Trends Biochem. Sci. 44, 33-52 (2019). Ziv, O., Gabryelska, M.M., Lun, A.T.L., Gebert, L.F.R., Sheu-Gruttadauria, J., Meredith, L.W., Liu, Z.Y., Kwok, C.K., Qin, C.F., MacRae, I.J., Goodfellow, I., Marioni, J.C., Kudla, G., Miska, E.A. COMRADES determines in vivo RNA structures and interactions. Nat Methods. 15, 785-788 (2018). Chan, K.L., Peng, B., Umar, M.I., Chan, C.-Y., Sahakyan, A.B., Le, M.T.N., Kwok, C.K. Structural Analysis Reveals Formation and Role of RNA G-Quadruplex Structures in Human Mature MicroRNAs. Chem Comm. 54, 10878-10881 (2018). Kwok, CK., Marsico, G., Balasubramanian, S. Detecting RNA G-quadruplexes (rG4s) in the Transcriptome. Cold Spring Harb Perspect Biol. 10:a032284 (2018). Ding, Y., Kwok, CK. Emergence of Vascular Plants. Nature Plants 4, 325–326 (2018). |
Recent lab news: Sept 2019: Congratulations to Danyang and Xi for their new paper in Analytical Methods! Sept 2019: Kaixin was awarded one of the best poster awards in the G4 conference. Congratulations! Jul 2019: A big welcome to Haizhou Zhao who joined Kwok Lab as a Ph.D. student. Jul 2019: Paper published in Molecules! Congratulations to Mubarak, Danyang and Jamie! More coming soon! Jul 2019: We have received the General Research Fund (GRF) grant from Research Grants Council (RGC) of Hong Kong! Jun 2019: Sally Feng joined Kwok Lab as undergraduate student! A big welcome to Sally! Jun 2019: Our new paper is now published in Sci. Rep.! Congratulation to Michelle, Jieyu, and Xi! May 2019: Our undergraduates Daisy and Michelle have just graduated! Congrats! Mar 2019: Our new paper is now published in Trends Biochem. Sci. (Technology of the month)! Congratulation to Jieyu and Michelle! Feb 2019: Our new paper is now online in Chem Comm.! Congrats to Jamie and Mubarak! Jan 2019: Phoebe Wong joined Kwok Lab as undergraduate student. Welcome! Dec 2018: Our undergraduates Jamie and Megan have just graduated! Congratulations! Nov 2018: Our new paper is now published in Trends Biochem. Sci.! Congrats to Jieyu and Michelle! Oct 2018: Happy 2nd year anniversary to the Kwok Lab. Happy to see a 900% growth in the size of Kwok lab in 2 years! |