Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Zhao, H., Wong, H.Y., Ji, D., Lyu, K. & Kwok, C.K. Novel L-RNA Aptamer Controls APP Gene Expression in Cells by Targeting RNA G-Quadruplex Structure. ACS Appl. Mater. Interfaces. DOI: 10.1021/acsami.2c06390 (2022). Chen, X., Xue, G., Zhao, J. et al. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation. Cell Rep. 39, 110927 (2022). Georgakopoulos-Soares, I., Parada, G.E., Wong, H.Y. et al. Alternative splicing modulation by G-quadruplexes. Nat Commun 13, 2404 (2022). Xu, B., Zhu, Y., Cao, C., Chen, H., Jin, Q., Li, G., Ma, J., Zhao, J., Zhu, J., Ding, Y. et al. Recent advances in RNA structurome. SCIENCE CHINA Life Sciences. DOI: 10.1007/s11427-021-2116-2 (2022). Umar, M.I., Chan, CY. & Kwok, C.K. Development of RNA G-quadruplex (rG4)-targeting L-RNA aptamers by rG4-SELEX. Nat Protoc. DOI: https://doi.org/10.1038/s41596-022-00679-6 (2022). Georgakopoulos-Soares, I., Victorino, J., Parada, G.E. et al. High-throughput characterization of the role of non-B DNA motifs on promoter function. Cell Genomics. 2, 100111 (2022). Feng, H. & Kwok, C.K. Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures. RSC Chem. Biol. 3, 431- 435 (2022). |
Recent lab news: Jun 2022: Paper published in ACS Applied Materials & Interfaces! Congrats to Haizhou, Phoebe, Danyang and Kaixin! Jun 2022: Graduation of our undergraduate Kelly! Congratulations! Jun 2022: Paper published in Cell Reports! Congrats to Jieyu! May 2022: Congratulations to Beatrice for winning the Merit Prize of 'The 8th Hong Kong University Student Innovation and Entrepreneurship Competition'! May 2022: Congratulations to Danyang for winning the Beyotime Rising-Star Award for Scientists! May 2022: Our new paper is now online in Nature Communications. Congratulations to Phoebe! Apr 2022: New paper published in SCIENCE CHINA Life Sciences! Congratulations to Jieyu! Apr 2022: Paper published and has been featured in Nature Protocols! Congratulations! Mar 2022: Our new paper is now online in Cell Genomics! Congratulations to Phoebe! Mar 2022:Welcome Kun as a new Postdoc member of Kwok Lab! |