Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
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Recent publications: Qian, X., Zhao, J., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Revealing LncRNA Structures and Interactions by sequencing-based approaches. Trends Biochem. Sci. (2018) https://doi.org/10.1016/j.tibs.2018.09.012 Ziv, O., Gabryelska, M.M., Lun, A.T.L., Gebert, L.F.R., Sheu-Gruttadauria, J., Meredith, L.W., Liu, Z.Y., Kwok, C.K., Qin, C.F., MacRae, I.J., Goodfellow, I., Marioni, J.C., Kudla, G., Miska, E.A. COMRADES determines in vivo RNA structures and interactions. Nat Methods. 15, 785-788 (2018). Chan, K.L., Peng, B., Umar, M.I., Chan, C.-Y., Sahakyan, A.B., Le, M.T.N., Kwok, C.K. Structural Analysis Reveals Formation and Role of RNA G-Quadruplex Structures in Human Mature MicroRNAs. Chem Comm. 54, 10878-10881 (2018). Kwok, CK., Marsico, G., Balasubramanian, S. Detecting RNA G-quadruplexes (rG4s) in the Transcriptome. Cold Spring Harb Perspect Biol. 10:a032284 (2018). Ding, Y., Kwok, CK. Emergence of Vascular Plants. Nature Plants 4, 325–326 (2018). Kwok, CK., Merrick, C.J. G-Quadruplexes: Prediction, Characterization, and Biological Application. Trends Biotechnol. 35, 997–1013 (2017). Norris, M., Kwok, CK., Cheema J., Hartley M., Morris R.J., Aviran S., Ding, Y. FoldAtlas: A Repository for Genome-Wide RNA Structure Probing Data. Bioinformatics. 33, 306-308 (2017). |
Recent lab news: Nov 2018: Our new paper was published in Trends Biochem. Sci.! Congrats! Oct 2018: Happy 2nd year anniversary to the Kwok Lab. Happy to see a 900% growth in the size of Kwok lab in 2 years! Sept 2018: Papers published in Nature Methods and Chem. Comm.! More is yet to come! Sept 2018: Danyang Ji joined the Kwok Lab as research assistant. Welcome! Jul 2018: Our review on RNA G-quadruplex is now online in Cold Spring Harb. Perspect Biol! Also as a book chapter in RNA Worlds: New tools for deep exploration, 5th Edition. Jul 2018: We have received the General Research Fund (GRF) grant from Research Grants Council (RGC) of Hong Kong! More is yet to come! May 2018: Xi Mou and Kaixin Lyu joined the Kwok Lab as PhD student. Welcome! Jan 2018: Our collaborator Prof. Qiangfeng Zhang from Tsinghua University visited us! |