Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
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Recent publications: Zhang, Y., Wu, Y., Zheng, H., Xi, H., Ye, T., Chan, C. Y. & Kwok, C.K. Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization. Anal. Chem., https://doi.org/10.1021/acs.analchem.0c04862 (2021). Lyu, K., Chow, E.Y.C., Mou, X., Chan, T. & Kwok, C.K. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res., gkab187 (2021). Zhao, H. & Kwok, C.K. Bringing distant DNA together. Nature Chem. Bio. 17, 125-126 (2021). Mou, X. & Kwok, C.K. Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction. Biochem. Biophys. Res.Commun. 533, 1135-1141 (2020). Umar, M.I. & Kwok, C.K. Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer. Nucleic Acids Res. 48, 10125-10141 (2020). Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol 21, 226 (2020). Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics 22, 1150-1160 (2020). Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology 17, 903-917 (2020). |
Recent lab news: March 2021: Our new paper is now published in Analytical Chemistry. Congrats to Jamie! March 2021: Paper published in Nucleic Acids Research! Congrats to Kaixin and Xi! Jan 2021: New paper published in Nature Chemical Biology! Congratulations to Haizhou! Jan 2021: A big welcome to Beatrice as a new UG member of Kwok Lab! Dec 2020: Welcome Andrea as a new postdoc (part time) in Kwok Lab! Oct 2020: Our new paper is now online in Biochemical and Biophysical Research Communications! Congratulations to Xi! Sep 2020: Paper published in Nucleic Acids Research! Congrats to Mubarak! Sep 2020: Happy graduation to Mubarak on the PhD programme! Congratulations! Sep 2020: Our new paper is now online in Genome Biol! Congratulations to Mubarak and Jieyu! July 2020: A big welcome to Caroline as a new UG member of Kwok Lab! June 2020: Our new paper is now published in Briefings in Bioinformatics! Congratulations to Danyang! April 2020: Paper published in RNA Biology! Congratulations to Kaixin! More coming soon! |