Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
|
What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
|
Recent publications: Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics DOI: https://doi.org/10.1093/bib/bbaa114 (2020). Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology 17, 903-917 (2020). Chan, C. Y., & Kwok, C. K. Specific Binding of a D‐RNA G‐Quadruplex Structure with an L‐RNA Aptamer. Angew. Chem. Int. Ed. 59, 5293 –5297 (2020). Shao, X., Zhang, W., Umar, M. I., Wong, H. Y., Seng, Z., Xie, Y., Zhang, Y., Yang, L., Kwok, C. K. & Deng, X. RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria. mBio 11, 1 (2020). Ji, D., Li, Z., & Kwok, C.K. Rational design and development of a universal baby spinach-based sensing platform for the detection of biomolecules. Analyst 144, 7173 - 7177 (2019). Lyu, K., Chen, S. B., Chan, C.-Y., Tan, J. H., & Kwok, C.K. Structural analysis and cellular visualization of APP RNA G-quadruplex. Chemical Science. 10, 11095 - 11102 (2019). Ji, D., Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Analytical Methods 11, 4808 - 4813 (2019). Umar, M.I.; Ji, D.; Chan, C.-Y.; Kwok, C.K. G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications. Molecules 24, 2416 (2019). Yeung, P.Y., Zhao, J., Chow, E.Y.C., Mou, X., Hong, H.Q., Chen, L.L., Chan, T.F., Kwok, C.K. Systematic evaluation and optimization of the experimental steps in RNA G-quadruplex structure sequencing. Sci. Rep. 9, 8091 (2019). Zhao, J., Qian, X., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Mapping In Vivo RNA Structures and Interactions. Trends Biochem. Sci. 44, 555-556 (2019). |
Recent lab news: June 2020: Our new paper is now published in Briefings in Bioinformatics! Congratulations to Danyang! April 2020: Paper published in RNA Biology! Congratulations to Kaixin! More coming soon! Jan 2020: Our new paper is now published in Angew. Chem. Int. Ed.. Congrats to Jamie! Jan 2020: Dr. Kwok was awarded the 2019 CityU President Award and 2019 Croucher Innovation Award! Congratulations! Jan 2020: Our new paper is now published in mBio! Congratulations to Mubarak and Phoebe! Nov 2019: Paper published in Analyst! Congrats to Danyang! Oct 2019: Our new paper is now online in Chemical Science! Congratulations to Kaixin and Jamie! Sept 2019: Congratulations to Danyang and Xi on their new paper in Analytical Methods! Sept 2019: Kaixin was awarded one of the best poster awards in the G4 conference. Congratulations! Jul 2019: A big welcome to Haizhou Zhao who joined Kwok Lab as a Ph.D. student. Jul 2019: Paper published in Molecules! Congratulations to Mubarak, Danyang and Jamie! More coming soon! Jul 2019: We have received the General Research Fund (GRF) grant from Research Grants Council (RGC) of Hong Kong! Jun 2019: Sally Feng joined Kwok Lab as undergraduate student! A big welcome to Sally! Jun 2019: Our new paper is now published in Sci. Rep.! Congratulation to Michelle, Jieyu, and Xi! |