Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer and NGS Development Funding sources:
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Recent publications: Chen, X., Yuan, J., Xue, G. et al. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun 12, 5043 (2021). Ji, D., Lyu, K., Zhao, H. & Kwok, C.K. Circular L-RNA aptamer promotes target recognition and controls gene activity. Nucleic Acids Res. 49, 7280-7291 (2021). Zhang, Y., Wu, Y., Zheng, H., Xi, H., Ye, T., Chan, C. Y. & Kwok, C.K. Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization. Anal. Chem. 93, 5744-5753 (2021). Lyu, K., Chow, E.Y.C., Mou, X., Chan, T. & Kwok, C.K. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 49, 5426-5450 (2021). Zhao, H. & Kwok, C.K. Bringing distant DNA together. Nature Chem. Bio. 17, 125-126 (2021). Mou, X. & Kwok, C.K. Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction. Biochem. Biophys. Res.Commun. 533, 1135-1141 (2020). Umar, M.I. & Kwok, C.K. Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer. Nucleic Acids Res. 48, 10125-10141 (2020). Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol 21, 226 (2020). |
Recent lab news: Sep 2021: Welcome Beijia as a new UG member of Kwok Lab! Aug 2021: Our new paper is now online in Nature Communications! Congratulations to Xi, Caroline and Mubarak! Jul 2021: Farewell! Best wishes to your postdoc journey, Mubarak! Jul 2021: Paper published in Nucleic Acids Research! Congrats to Danyang, Kaixin and Haizhou! Jul 2021: Congratulations to Dr Kwok on the promotion! May 2021: Happy Graduation to our undergraduates Caroline and Phoebe! Congratulations! March 2021: Our new paper is now published in Analytical Chemistry. Congrats to Jamie! March 2021: Paper published in Nucleic Acids Research! Congrats to Kaixin and Xi! Jan 2021: New paper published in Nature Chemical Biology! Congratulations to Haizhou! Jan 2021: A big welcome to Beatrice as a new UG member of Kwok Lab! Dec 2020: Welcome Andrea as a new postdoc (part time) in Kwok Lab! Oct 2020: Our new paper is now online in Biochemical and Biophysical Research Communications! Congratulations to Xi! |