Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Lyu, K, Chen, S.B., Chow, E.Y., Zhao, H., Yuan, J.H., Cai, M., Shi, J., Chan, T.F., Tan, J.H., Kwok, C.K. An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation. Angewandte Chemie. e20203553 (2022). Zhao, J., Chow, E.U., Yeung, P.Y., Zhang, Q.C., Chan, T.F., Kwok, C.K. Enhanced transcriptome-wide RNA G-Quadruplex sequencing for low RNA input samples with rG4-seq 2.0. BMC Biology. 20, 257 (2022). Yang, X., Yu, H., Duncan, S., Zhang, Y., Cheema, J., Liu, H., Miller, J.B., Zhang, J., Kwok, C.K., Zhang, H., Ding, Y. RNA G-quadruplex structure contributes to cold adaptation in plants. Nat Commun. 13, 6224 (2022). Dumetz, F., Enright, A.J., Zhao, J., Kwok, C.K, Merrick, C.J. The in vivo RNA structurome of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome. Plos One. 17(9), e0270863 (2022). Zhang, Y., Juhas, M., Kwok, C. K. Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19. Trends in Biotechnology. DOI: https://doi.org/10.1016/j.tibtech.2022.07.012 Zhao, H., Wong, H.Y., Ji, D., Lyu, K. & Kwok, C.K. Novel L-RNA Aptamer Controls APP Gene Expression in Cells by Targeting RNA G-Quadruplex Structure. ACS Appl. Mater. Interfaces. 14, 30582- 30594 (2022). Chen, X., Xue, G., Zhao, J. et al. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation. Cell Rep. 39, 110927 (2022). |
Recent lab news: Nov 2022: Paper published in Angewandte Chemie. Congrats to Kaixin and Haizhou! Nov 2022: Paper published in BMC Biology. Congrats to Jieyu! Sep 2022: Paper published in Plos One. Congrats to Jieyu! Jun 2022: Paper published in ACS Applied Materials & Interfaces! Congrats to Haizhou, Phoebe, Danyang and Kaixin! Jun 2022: Graduation of our undergraduate Kelly! Congratulations! Jun 2022: Paper published in Cell Reports! Congrats to Jieyu! May 2022: Congratulations to Beatrice for winning the Merit Prize of 'The 8th Hong Kong University Student Innovation and Entrepreneurship Competition'! May 2022: Congratulations to Danyang for winning the Beyotime Rising-Star Award for Scientists! May 2022: Our new paper is now online in Nature Communications. Congratulations to Phoebe! Apr 2022: New paper published in SCIENCE CHINA Life Sciences! Congratulations to Jieyu! Apr 2022: Paper published and has been featured in Nature Protocols! Congratulations! |