Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email ([email protected]) with CV and research background if interested.
Email ([email protected]) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Lam, S. Y., Li, P., Jin, L., Chan, H. Y., Ruan, Y., Kwok, C. K., Lo, P. K. Enhanced detection of Enrofloxacin in Seawater using a newly selected Aptamer on a graphite oxide-based biosensor. Analytical Chemistry. 97(12), 6735-6744 (2025). Liew, S. W., Cao, D., Petersen, R. J., Butcher, S. E., Kennedy, S. G., Kwok, C. K. A novel L-RNA aptamer to regulate the pUG fold RNA-induced gene expression in vivo. Nucleic Acids Res. 53(5), gkaf137 (2025). Zhang, K., Nie, Q., Li, M., Chen, X., Zhong, L., Dai, T., Guo, X., Zhao, H., Lau, T. C., Wang, H., Chen, S. B., Kwok, C. K. RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. Nucleic Acids Res. 53(3). gkaf03 (2025). Ji, D., Wang, B., Lo, K. W., Tsang, C. M., Kwok, C. K. Pre-Defined Stem-Loop Structure Library for the Discovery of L-RNA Aptamers that Target RNA G-quadruplexes. Angew. Chem. Int. Ed. 64(5). e202417247 (2024). Zhang,Y., Zhao, J., Chen, X., Qiao, Y., Kang, J., Guo, X., Yang, F., Lyu, K., Ding, Y., Zhao, Y., Sun, H., Kwok, C. K., Wang, H. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nat. Commun. 15, 9890 (2024). Zhao, H., Lau, H. L., Zhang, K., Kwok, C. K. Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer-D-oligonucleotide conjugate. Nucleic Acids Res. 52(22), 13544-13560 (2024) |
Recent lab news: Apr 2025: Farewell, Aurell! Mar 2025: Paper published in Analytical Chemistry. Congrats to Beatrice! Mar 2025: Paper published in Nucleic Acid Research. Congrats to Caroline! Feb 2025: Paper published in Nucleic Acids Research. Congrats to Kun! Jan 2025: Congrats to Dr. Kwok on receiving RGC Research Fellow Award! Nov 2024: Paper published in Angewandte Chemie. Congrats to Danyang! Nov 2024: Paper published in Nature Communication. Congrats to Jieyu! Nov 2024: Paper published in Nucleic Acids Research. Congrats to Haizhou, Kelly, and Kun! Oct 2024: Paper published in Chemical Communications. Congrats to Sally! Aug 2024: Paper published in Small Methods. Congrats to Kelly, Haizhou, and Sally! Aug 2024: Paper published in RSC Chemical Biology. Congrats to Beatrice, Haizhou, and Jieyu! Jun 2024: Congrats to Dr. Kwok on receiving RNA Society Early Career Award! |