Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
Email (ckkwok42@cityu.edu.hk) with CV and research background if interested.
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What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Xi, M., Kwok, C. K. Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation. JACS. (2023) Lyu, K., Kwok, C. K. RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays. Methods in Enzymology. (2023) Lyu, K., Kwok, C. K. A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression. ChemComm. 59, 8230 - 8233(2023). Ji, D., Feng, H., Liew, S. W., Kwok, C. K. Modified nucleic acid aptamers: development, characterization, and biological applications. Trends in Biotechnology (2023). Shiu, S. C., Kinghorn, A. B., Guo, W., Slaughter, L. S., Ji, D., Mo, X., Wang, L., Tran, N. C., Kwok, C. K., Shum, A. H. C., Tse, E. C. M., Tanner, J. A. Aptamers as Functional Modules for DNA Nanostructures. Methods Mol Biol. 2639, 301-337 (2023). Guo, W., Ji, D., Kinghorn, A. B., Chen, F., Pan, Y., Li, X., Li, Q., Huck, W. T. S., Kwok, C.K, Shum, H. C. Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condensates. JACS. 145, 2375-2385 (2023). Lam, S.Y., Lau, H.L., Kwok, C.K. Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application. Biosensors. 12(12), 1142 (2022). Lyu, K, Chen, S.B., Chow, E.Y., Zhao, H., Yuan, J.H., Cai, M., Shi, J., Chan, T.F., Tan, J.H., Kwok, C.K. An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation. Angewandte Chemie. 61, e20203553 (2022). |
Recent lab news: Aug 2023: Congrats to Sally on winning Outstanding Academic Performance Award (OAPA)! Aug 2023: Paper published in JACS. Congrats to Xi! Jun 2023: Paper published in Methods in Enzymology. Congrats to Kaixin! Jun 2023: CSCI Excellent Paper Award for Research Students. Congrats to Danyang, Sally and Caroline! Jun 2023: Paper published in ChemComm. Congrats to Kaixin! Jun 2023: Paper published in Trends in Biotechnology. Congrats to Danyang, Sally and Caroline! Jun 2023: Congrats to Jieyu on winning one of the best poster awards in RNA 2023! May 2023: Paper published in Methods Mol Biol. Congrats to Danyang! Mar 2023: CSCI Excellent Paper Award. Congrats to Danyang! Feb 2023: Congrats to Beatrice, Danyang and Sharon for securing HK Tech 300 and HKSTP Ideation Fund! Jan 2023: CSCI Excellent Paper Award. Congrats to Kaixin! Jan 2023: Paper published in JACS. Congrats to Danyang! Dec 2022: Paper published in Biosensors. Congrats to Beatrice and Kelly! |