​Exploring the Chemistry and Biology of Nucleic Acids​

PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
​Email ([email protected]) with CV and research background if interested.

​What our lab studies:

- G-quadruplex Structure and Function

- RNA Biology and Gene Regulation

- Aptamer Development and Application

Funding sources:

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​Recent publications:

Lau, H. L., Zhao, H., Feng, H., Kwok, C. K. Specific Targeting and Imaging of RNA G-quadruplex (rG4) Structure Using Non-G4-Containing L-RNA Aptamer and Fluorogenic L-Aptamer. Small Methods. e2401097 (2024)

Lam, S. Y., Umar, M. I., Zhao, H., Zhao, J., Kwok, C. K. Capture of RNA G-quadruplex structures using an L-RNA aptamer. RSC Chem. Biol.  5, 1045-1051 (2024)

Liu, Y., Shi, Y., Wang, S., Liu, S., Shang, M., Zhao, B., Liu, H., Yang, C., Wang, F.,  Kwok, C. K.,  Wang, H. Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria. Anal. Chem. 96, 11951-11958 (2024)

Zhang, K., Nie, Q., Lau, C. K., Kwok, C. K. Rational Design of L-RNA Aptamer-Peptide Conjugate for Efficient Cell Uptake and G-quadruplex-Mediated Gene Control. Angew. Chem. Int. Ed. 136, e202310798 (2024)

Ji, D., Yuan, J., Chen, S., Tan, J., Kwok, C. K. Selective targeting of parallel G-quadruplex structure using L-RNA aptamer. Nucleic Acids Res. 51, 11439–11452 (2023)

Mou, X., Kwok, C. K. Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation. JACS. 145, 18693−18697 (2023) 

Lyu, K., Kwok, C. K. RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays. Methods Enzymol. 691, 63-80 (2023)



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​Recent lab news:

Aug 2024: Paper published in Small Methods. Congrats to Kelly and Haizhou!

Aug 2024: Paper published in RSC Chemical Biology. Congrats to Beatrice, Haizhou, and Jieyu!

Jun 2024: Congrats to Dr. Kwok on receiving RNA Society Early Career Award!

May 2024: Congrats to Danyang on awarding Travel Awards for XXV IRT in Tokyo 2024!

Mar 2024: Congrats to Kaixin on awarding the Outstanding Research Thesis Award 2023!

Feb 2024: Congrats to Jesslyn on awarding HKSAR Government Scholarship 2023/2024!

Feb 2024: Congrats to Caroline and Kun on awarding the RNA Society Research Presentation Fellowship!

Jan 2024: Paper published in Angewandte Chemie. Congrats to Kun!

Oct 2023: Paper published in Nucleic Acids Research. Congrats to Danyang!

Aug 2023: Congrats to Sally on winning Outstanding Academic Performance Award (OAPA)!

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