Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email ([email protected]) with CV and research background if interested.
Email ([email protected]) with CV and research background if interested.
|
What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
|
Recent publications: Ji, D., Wang, B., Lo, K. W., Tsang, C. M., Kwok, C. K. Pre-Defined Stem-Loop Structure Library for the Discovery of L-RNA Aptamers that Target RNA G-quadruplexes. Angew. Chem. Int. Ed. e202417247 (2024). Zhang,Y., Zhao, J., Chen, X., Qiao, Y., Kang, J., Guo, X., Yang, F., Lyu, K., Ding, Y., Zhao, Y., Sun, H., Kwok, C. K., Wang, H. DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1. Nat. Commun. 15, 9890 (2024). Zhao, H., Lau, H. L., Zhang, K., Kwok, C. K. Selective recognition of RNA G-quadruplex in vitro and in cells by L-aptamer-D-oligonucleotide conjugate. Nucleic Acids Res. gkae1034 (2024) Feng, H., Kwok, C. K. A selective HIV-1 RNA G-quadruplex-targeting l-aptamer-d-antisense conjugate inhibits HIV-1 minus strand transfer. Chem. Commun. 60, 13558-13561 (2024) Lau, H. L., Zhao, H., Feng, H., Kwok, C. K. Specific Targeting and Imaging of RNA G-quadruplex (rG4) Structure Using Non-G4-Containing L-RNA Aptamer and Fluorogenic L-Aptamer. Small Methods. e2401097 (2024) Lam, S. Y., Umar, M. I., Zhao, H., Zhao, J., Kwok, C. K. Capture of RNA G-quadruplex structures using an L-RNA aptamer. RSC Chem. Biol. 5, 1045-1051 (2024) Liu, Y., Shi, Y., Wang, S., Liu, S., Shang, M., Zhao, B., Liu, H., Yang, C., Wang, F., Kwok, C. K., Wang, H. Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria. Anal. Chem. 96, 11951-11958 (2024) |
Recent lab news: Nov 2024: Paper published in Angewandte Chemie. Congrats to Danyang! Nov 2024: Paper published in Nature Communication. Congrats to Jieyu! Nov 2024: Paper published in Nucleic Acids Research. Congrats to Haizhou, Kelly, and Kun! Oct 2024: Paper published in Chemical Communications. Congrats to Sally! Aug 2024: Paper published in Small Methods. Congrats to Kelly, Haizhou, and Sally! Aug 2024: Paper published in RSC Chemical Biology. Congrats to Beatrice, Haizhou, and Jieyu! Jun 2024: Congrats to Dr. Kwok on receiving RNA Society Early Career Award! May 2024: Congrats to Danyang on awarding Travel Awards for XXV IRT in Tokyo 2024! Mar 2024: Congrats to Kaixin on awarding the Outstanding Research Thesis Award 2023! Feb 2024: Congrats to Jesslyn on awarding HKSAR Government Scholarship 2023/2024! Feb 2024: Congrats to Caroline and Kun on awarding the RNA Society Research Presentation Fellowship! |