Google Scholar link PUBMED link
2023
61. Shiu, S. C., Kinghorn, A. B., Guo, W., Slaughter, L. S., Ji, D., Mo, X., Wang, L., Tran, N. C., Kwok, C. K., Shum, A. H. C., Tse, E. C. M., Tanner, J. A. Aptamers as Functional Modules for DNA Nanostructures. Methods Mol Biol. 2639, 301-337 (2023). https://doi.org/10.1007/978-1-0716-3028-0_17
60. Guo, W., Ji, D., Kinghorn, A. B., Chen, F., Pan, Y., Li, X., Li, Q., Huck, W. T. S., Kwok, C.K, Shum, H. C. Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condesates. JACS. 145, 2375-2385 (2023). http://doi.org/10.1021/jacs.2c11362
60. Guo, W., Ji, D., Kinghorn, A. B., Chen, F., Pan, Y., Li, X., Li, Q., Huck, W. T. S., Kwok, C.K, Shum, H. C. Tuning Material States and Functionalities of G-Quadruplex-Modulated RNA-Peptide Condesates. JACS. 145, 2375-2385 (2023). http://doi.org/10.1021/jacs.2c11362
2022
59. Lam, S.Y., Lau, H.L., Kwok, C.K. Capture-SELEX: Selection Strategy, Aptamer Identification, and Biosensing Application. Biosensors. 12(12), 1142 (2022). https://doi.org/10.3390/bios12121142
58. Lyu, K, Chen, S.B., Chow, E.Y., Zhao, H., Yuan, J.H., Cai, M., Shi, J., Chan, T.F., Tan, J.H., Kwok, C.K. An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation. Angewandte Chemie. 61, e20203553 (2022). https://doi.org/10.1002/anie.202203553
57. Zhao, J., Chow, E.U., Yeung P.Y., Zhang, Q.C., Chan, T.F., Kwok, C.K. Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0. BMC Biology. 20, 257 (2022). https://doi.org/10.1186/s12915-022-01448-3
56. Yang, X., Yu, H., Duncan, S., Zhang, Y., Cheema, J., Liu, H., Miller, J.B., Zhang, J., Kwok, C.K., Zhang, H., Ding, Y. RNA G-quadruplex structure contributes to cold adaptation in plants. Nat Commun. 13, 6224 (2022). https://doi.org/10.1038/s41467-022-34040-y
55. Dumetz, F., Enright, A.J., Zhao, J., Kwok, C.K., Merrick, C.J. The in vivo RNA structuromone of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome. Plos One. 17(9), e0270863 (2022). https://doi.org/10.1371/journal.pone.0270863
54. Zhang, Y., Juhas, M., Kwok, C. K. Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19. Trends in Biotechnology. 41, 528 - 544 (2022). https://doi.org/10.1016/j.tibtech.2022.07.012
53. Zhao, H., Wong, H.Y., Ji, D., Lyu, K. & Kwok, C.K. Novel L-RNA Aptamer Controls APP Gene Expression in Cells by Targeting RNA G-Quadruplex Structure. ACS Appl. Mater. Interfaces. 14, 30582 - 30594 (2022).https://doi.org/10.1021/acsami.2c06390
52. Chen, X., Xue, G., Zhao, J., Zhang, Y., Zhang, Z., Wang, W., Li, Y., Yuan, J., He, J., Chan, C.Y., Liu, Y., Chen, W., Zhao, Y., Hu, P., Sun, H., Kwok, C.K. & Wang, H. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation. Cell Rep. 39, 110927 (2022). https://doi.org/10.1016/j.celrep.2022.110927
51. Georgakopoulos-Soares, I., Parada, G.E., Wong, H.Y., Medhi, R., Furlan, G., Munita, R., Miska, E.A., Kwok, C.K. & Hemberg, M. Alternative splicing modulation by G-quadruplexes. Nat Commun. 13, 2404 (2022). https://doi.org/10.1038/s41467-022-30071-7
50. Xu, B., Zhu, Y., Cao, C., Chen, H., Jin, Q., Li, G., Ma, J., Zhao, J., Zhu, J., Ding, Y., Fang, X., JIN, Y., Kwok, C.K., Ren, A., Wan, Y., Wang, Z., Xue, Y., Zhang, H., Zhang, Q. & Zhou,Y. Recent advances in RNA structurome. SCIENCE CHINA Life Sciences. 65, 1285- 1324 (2022). https://doi.org/10.1007/s11427-021-2116-2
49. Umar, M.I., Chan, CY. & Kwok, C.K. Development of RNA G-quadruplex (rG4)-targeting L-RNA aptamers by rG4-SELEX. Nat Protoc. 17, 1385-1414 (2022). https://doi.org/10.1038/s41596-022-00679-6
48. Georgakopoulos-Soares, I., Victorino, J., Parada, G.E., Agarwal, V., Zhao, J., Wong, H.Y., Umar, M,I., Elor, O., Muhwezi, A., An, J., Sanders, S.J., Kwok, C.K., Inoue, F., Hemberg, M. & Ahituv, N. High-throughput characterization of the role of non-B DNA motifs on promoter function. Cell Genomics. 2, 100111 (2022). https://doi.org/10.1016/j.xgen.2022.100111
47. Feng, H, & Kwok, C.K. Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures. RSC Chem. Biol. 3, 431- 435 (2022). https://doi.org/10.1039/d2cb00045h
46. Piao, M., Li, P., Zeng, X., Wang, X., Kang, L., Zhang, J., Wei, Y., Zhang, S., Tang, L., Zhu, J., Kwok, C.K., Hu, X. & Zhang, Q.F.C. An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages. Fundamental Research. 2, 2-13 (2022). https://doi.org/10.1016/j.fmre.2021.12.007
45. Mou, X., Liew, S. W. & Kwok, C.K. Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA. Nucleic Acids Res. 50, 397- 410 (2022). https://doi.org/10.1093/nar/gkab1208
58. Lyu, K, Chen, S.B., Chow, E.Y., Zhao, H., Yuan, J.H., Cai, M., Shi, J., Chan, T.F., Tan, J.H., Kwok, C.K. An RNA G-Quadruplex Structure within the ADAR 5'UTR Interacts with DHX36 Helicase to Regulate Translation. Angewandte Chemie. 61, e20203553 (2022). https://doi.org/10.1002/anie.202203553
57. Zhao, J., Chow, E.U., Yeung P.Y., Zhang, Q.C., Chan, T.F., Kwok, C.K. Enhanced transcriptome-wide RNA G-quadruplex sequencing for low RNA input samples with rG4-seq 2.0. BMC Biology. 20, 257 (2022). https://doi.org/10.1186/s12915-022-01448-3
56. Yang, X., Yu, H., Duncan, S., Zhang, Y., Cheema, J., Liu, H., Miller, J.B., Zhang, J., Kwok, C.K., Zhang, H., Ding, Y. RNA G-quadruplex structure contributes to cold adaptation in plants. Nat Commun. 13, 6224 (2022). https://doi.org/10.1038/s41467-022-34040-y
55. Dumetz, F., Enright, A.J., Zhao, J., Kwok, C.K., Merrick, C.J. The in vivo RNA structuromone of the malaria parasite Plasmodium falciparum, a protozoan with an A/U-rich transcriptome. Plos One. 17(9), e0270863 (2022). https://doi.org/10.1371/journal.pone.0270863
54. Zhang, Y., Juhas, M., Kwok, C. K. Aptamers targeting SARS-COV-2: a promising tool to fight against COVID-19. Trends in Biotechnology. 41, 528 - 544 (2022). https://doi.org/10.1016/j.tibtech.2022.07.012
53. Zhao, H., Wong, H.Y., Ji, D., Lyu, K. & Kwok, C.K. Novel L-RNA Aptamer Controls APP Gene Expression in Cells by Targeting RNA G-Quadruplex Structure. ACS Appl. Mater. Interfaces. 14, 30582 - 30594 (2022).https://doi.org/10.1021/acsami.2c06390
52. Chen, X., Xue, G., Zhao, J., Zhang, Y., Zhang, Z., Wang, W., Li, Y., Yuan, J., He, J., Chan, C.Y., Liu, Y., Chen, W., Zhao, Y., Hu, P., Sun, H., Kwok, C.K. & Wang, H. Lockd promotes myoblast proliferation and muscle regeneration via binding with DHX36 to facilitate 5′ UTR rG4 unwinding and Anp32e translation. Cell Rep. 39, 110927 (2022). https://doi.org/10.1016/j.celrep.2022.110927
51. Georgakopoulos-Soares, I., Parada, G.E., Wong, H.Y., Medhi, R., Furlan, G., Munita, R., Miska, E.A., Kwok, C.K. & Hemberg, M. Alternative splicing modulation by G-quadruplexes. Nat Commun. 13, 2404 (2022). https://doi.org/10.1038/s41467-022-30071-7
50. Xu, B., Zhu, Y., Cao, C., Chen, H., Jin, Q., Li, G., Ma, J., Zhao, J., Zhu, J., Ding, Y., Fang, X., JIN, Y., Kwok, C.K., Ren, A., Wan, Y., Wang, Z., Xue, Y., Zhang, H., Zhang, Q. & Zhou,Y. Recent advances in RNA structurome. SCIENCE CHINA Life Sciences. 65, 1285- 1324 (2022). https://doi.org/10.1007/s11427-021-2116-2
49. Umar, M.I., Chan, CY. & Kwok, C.K. Development of RNA G-quadruplex (rG4)-targeting L-RNA aptamers by rG4-SELEX. Nat Protoc. 17, 1385-1414 (2022). https://doi.org/10.1038/s41596-022-00679-6
48. Georgakopoulos-Soares, I., Victorino, J., Parada, G.E., Agarwal, V., Zhao, J., Wong, H.Y., Umar, M,I., Elor, O., Muhwezi, A., An, J., Sanders, S.J., Kwok, C.K., Inoue, F., Hemberg, M. & Ahituv, N. High-throughput characterization of the role of non-B DNA motifs on promoter function. Cell Genomics. 2, 100111 (2022). https://doi.org/10.1016/j.xgen.2022.100111
47. Feng, H, & Kwok, C.K. Spectroscopic analysis reveals the effect of hairpin loop formation on G-quadruplex structures. RSC Chem. Biol. 3, 431- 435 (2022). https://doi.org/10.1039/d2cb00045h
46. Piao, M., Li, P., Zeng, X., Wang, X., Kang, L., Zhang, J., Wei, Y., Zhang, S., Tang, L., Zhu, J., Kwok, C.K., Hu, X. & Zhang, Q.F.C. An ultra low-input method for global RNA structure probing uncovers Regnase-1-mediated regulation in macrophages. Fundamental Research. 2, 2-13 (2022). https://doi.org/10.1016/j.fmre.2021.12.007
45. Mou, X., Liew, S. W. & Kwok, C.K. Identification and targeting of G-quadruplex structures in MALAT1 long non-coding RNA. Nucleic Acids Res. 50, 397- 410 (2022). https://doi.org/10.1093/nar/gkab1208
2021
44. Dumetz, F., Chow, E.Y.C., Harris, L.M., Liew, S.W., Jensen, A., Umar, M.I., Chung, B., Chan, T.F., Merrick, C.J. & Kwok, C.K. G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum. Nucleic Acids Res. 49, 12486–12501 (2021). https://doi.org/10.1093/nar/gkab1095
43. Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W., Mou, X., Liew, S.W., Umar, M.I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C.J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y., Nagamine, Y., Kwok, C.K., Sun, H., Muñoz-Cánoves, P. & Wang, H. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun 12, 5043 (2021). https://doi.org/10.1038/s41467-021-25170-w
42. Ji, D., Lyu, K., Zhao, H. & Kwok, C.K. Circular L-RNA aptamer promotes target recognition and controls gene activity. Nucleic Acids Res. 49, 7280-7291 (2021). https://doi.org/10.1093/nar/gkab593
41. Zhang, Y., Wu, Y., Zheng, H., Xi, H., Ye, T., Chan, C. Y. & Kwok, C.K. Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization. Anal. Chem. 93, 5744-5753 (2021). https://doi.org/10.1021/acs.analchem.0c04862
40. Lyu, K., Chow, E.Y.C., Mou, X., Chan, T. & Kwok, C.K. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 49, 5426-5450 (2021). https://doi.org/10.1093/nar/gkab187
39. Zhao, H. & Kwok, C.K. Bringing distant DNA together. Nature Chem. Bio. 17, 125-126 (2021). https://doi.org/10.1038/s41589-020-00705-2
43. Chen, X., Yuan, J., Xue, G., Campanario, S., Wang, D., Wang, W., Mou, X., Liew, S.W., Umar, M.I., Isern, J., Zhao, Y., He, L., Li, Y., Mann, C.J., Yu, X., Wang, L., Perdiguero, E., Chen, W., Xue, Y., Nagamine, Y., Kwok, C.K., Sun, H., Muñoz-Cánoves, P. & Wang, H. Translational control by DHX36 binding to 5’UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun 12, 5043 (2021). https://doi.org/10.1038/s41467-021-25170-w
42. Ji, D., Lyu, K., Zhao, H. & Kwok, C.K. Circular L-RNA aptamer promotes target recognition and controls gene activity. Nucleic Acids Res. 49, 7280-7291 (2021). https://doi.org/10.1093/nar/gkab593
41. Zhang, Y., Wu, Y., Zheng, H., Xi, H., Ye, T., Chan, C. Y. & Kwok, C.K. Proteomic and Transcriptome Profiling of G-Quadruplex Aptamers Developed for Cell Internalization. Anal. Chem. 93, 5744-5753 (2021). https://doi.org/10.1021/acs.analchem.0c04862
40. Lyu, K., Chow, E.Y.C., Mou, X., Chan, T. & Kwok, C.K. RNA G-quadruplexes (rG4s): genomics and biological functions. Nucleic Acids Res. 49, 5426-5450 (2021). https://doi.org/10.1093/nar/gkab187
39. Zhao, H. & Kwok, C.K. Bringing distant DNA together. Nature Chem. Bio. 17, 125-126 (2021). https://doi.org/10.1038/s41589-020-00705-2
2020
38. Mou, X. & Kwok, C.K. Effect of RNA sequence context and stereochemistry on G-quadruplex-RHAU53 interaction. Biochem. Biophys. Res. Commun. 533, 1135-1141 (2020). https://doi.org/10.1016/j.bbrc.2020.09.045
37. Umar, M.I. & Kwok, C.K. Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer. Nucleic Acids Res. 48, 10125-10141 (2020). https://doi.org/10.1093/nar/gkaa759
36. Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol. 21, 226 (2020). https://doi.org/10.1186/s13059-020-02142-9
35. Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics. 22, 1150-1160 (2020). https://doi.org/10.1093/bib/bbaa114
34. Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology. 17, 903-917 (2020). https://doi.org/10.1080/15476286.2020.1740470
33. Chan, C. Y., & Kwok, C. K. Specific Binding of a D‐RNA G‐Quadruplex Structure with an L‐RNA Aptamer. Angew. Chem. Int. Ed. 59, 5293 –5297 (2020). https://doi.org/10.1002/anie.201914955
32. Shao, X., Zhang, W., Umar, M. I., Wong, H. Y., Seng, Z., Xie, Y., Zhang, Y., Yang, L., Kwok, C. K. & Deng, X. RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria. mBio 11, 1 (2020). https://doi.org/10.1128/mbio.02926-19
37. Umar, M.I. & Kwok, C.K. Specific suppression of D-RNA G-quadruplex–protein interaction with an L-RNA aptamer. Nucleic Acids Res. 48, 10125-10141 (2020). https://doi.org/10.1093/nar/gkaa759
36. Yang, X., Cheema, J., Zhang, Y., Deng, H., Duncan, S., Umar, M. I., Zhao, J., Liu, Q., Cao, X., Kwok, C. K. & Ding, Y. RNA G-quadruplex structures exist and function in vivo in plants. Genome Biol. 21, 226 (2020). https://doi.org/10.1186/s13059-020-02142-9
35. Ji, D., Juhas, M., Tsang, C. M., Kwok, C. K., Li, Y. & Zhang, Y. Discovery of G-quadruplex-forming sequences in SARS-CoV-2. Briefings in Bioinformatics. 22, 1150-1160 (2020). https://doi.org/10.1093/bib/bbaa114
34. Chow, E.Y.C., Lyu, K., Kwok, C. K. & Chan, T.F. rG4-seeker enables high-confidence identification of novel and non-canonical rG4 motifs from rG4-seq experiments. RNA Biology. 17, 903-917 (2020). https://doi.org/10.1080/15476286.2020.1740470
33. Chan, C. Y., & Kwok, C. K. Specific Binding of a D‐RNA G‐Quadruplex Structure with an L‐RNA Aptamer. Angew. Chem. Int. Ed. 59, 5293 –5297 (2020). https://doi.org/10.1002/anie.201914955
32. Shao, X., Zhang, W., Umar, M. I., Wong, H. Y., Seng, Z., Xie, Y., Zhang, Y., Yang, L., Kwok, C. K. & Deng, X. RNA G-Quadruplex Structures Mediate Gene Regulation in Bacteria. mBio 11, 1 (2020). https://doi.org/10.1128/mbio.02926-19
2019
31. Ji, D., Li, Z., & Kwok, C. K. Rational design and development of a universal baby spinach-based sensing platform for the detection of biomolecules. Analyst. 144, 7173 - 7177 (2019). https://doi.org/10.1039/c9an02061f
30. Lyu, K., Chen, S. B., Chan, C. Y., Tan, J. H., & Kwok, C. K. Structural analysis and cellular visualization of APP RNA G-quadruplex. Chemical Science. 10, 11095 - 11102 (2019). https://doi.org/10.1039/c9sc02768h
29. Ji, D., Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Analytical Methods 11, 4808 - 4813 (2019). https://doi.org/10.1039/C9AY01891C
28. Umar, M.I.; Ji, D.; Chan, C.-Y.; Kwok, C.K. G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications. Molecules 24, 2416 (2019). https://doi.org/10.3390/molecules24132416
27. Yeung, P.Y., Zhao, J., Chow, E.Y.C., Mou, X., Hong, H.Q., Chen, L.L., Chan, T.F., Kwok, C.K. Systematic evaluation and optimization of the experimental steps in RNA G-quadruplex structure sequencing. Sci. Rep. 9, 8091 (2019). https://doi.org/10.1038/s41598-019-44541-4
26. Zhao, J., Qian, X., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Mapping In Vivo RNA Structures and Interactions. Trends Biochem. Sci. 44, 555-556 (2019). https://doi.org/10.1016/j.tibs.2019.01.012
25. Chan, C.-Y., Umar, M.I., Kwok, C.K. Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures. Chem Comm. 55, 2616-2619 (2019). https://doi.org/10.1039/c8cc09929d
24. Qian, X., Zhao, J., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Revealing LncRNA Structures and Interactions by Sequencing-Based Approaches. Trends Biochem. Sci. 44, 33-52 (2019). https://doi.org/10.1016/j.tibs.2018.09.012
30. Lyu, K., Chen, S. B., Chan, C. Y., Tan, J. H., & Kwok, C. K. Structural analysis and cellular visualization of APP RNA G-quadruplex. Chemical Science. 10, 11095 - 11102 (2019). https://doi.org/10.1039/c9sc02768h
29. Ji, D., Mou, X., Kwok, C.K. Label-free and ratiometric detection of microRNA based on target-induced catalytic hairpin assembly and two fluorescent dyes. Analytical Methods 11, 4808 - 4813 (2019). https://doi.org/10.1039/C9AY01891C
28. Umar, M.I.; Ji, D.; Chan, C.-Y.; Kwok, C.K. G-Quadruplex-Based Fluorescent Turn-On Ligands and Aptamers: From Development to Applications. Molecules 24, 2416 (2019). https://doi.org/10.3390/molecules24132416
27. Yeung, P.Y., Zhao, J., Chow, E.Y.C., Mou, X., Hong, H.Q., Chen, L.L., Chan, T.F., Kwok, C.K. Systematic evaluation and optimization of the experimental steps in RNA G-quadruplex structure sequencing. Sci. Rep. 9, 8091 (2019). https://doi.org/10.1038/s41598-019-44541-4
26. Zhao, J., Qian, X., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Mapping In Vivo RNA Structures and Interactions. Trends Biochem. Sci. 44, 555-556 (2019). https://doi.org/10.1016/j.tibs.2019.01.012
25. Chan, C.-Y., Umar, M.I., Kwok, C.K. Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures. Chem Comm. 55, 2616-2619 (2019). https://doi.org/10.1039/c8cc09929d
24. Qian, X., Zhao, J., Yeung, P.Y., Zhang, Q.F.C., Kwok, C.K. Revealing LncRNA Structures and Interactions by Sequencing-Based Approaches. Trends Biochem. Sci. 44, 33-52 (2019). https://doi.org/10.1016/j.tibs.2018.09.012
2018
23. Ziv, O., Gabryelska, M.M., Lun, A.T.L., Gebert, L.F.R., Sheu-Gruttadauria, J., Meredith, L.W., Liu, Z.Y., Kwok, C.K., Qin, C.F., MacRae, I.J., Goodfellow, I., Marioni, J.C., Kudla, G., Miska, E.A. COMRADES determines in vivo RNA structures and interactions. Nat Methods. 15, 785-788 (2018). https://doi.org/10.1038/s41592-018-0121-0
22. Chan, K.L., Peng, B., Umar, M.I., Chan, C.-Y., Sahakyan, A.B., Le, M.T.N., Kwok, C.K. Structural Analysis Reveals Formation and Role of RNA G-Quadruplex Structures in Human Mature MicroRNAs. Chem Comm. 54, 10878-10881 (2018). https://doi.org/10.1039/c8cc04635b
21. Kwok, CK., Marsico, G., Balasubramanian, S. Detecting RNA G-quadruplexes (rG4s) in the Transcriptome. Cold Spring Harb Perspect Biol. 10:a032284 (2018). https://doi.org/10.1101/cshperspect.a032284
20. Ding, Y., Kwok, CK. Emergence of Vascular Plants. Nature Plants 4, 325–326 (2018). https://doi.org/10.1038/s41477-018-0159-0
22. Chan, K.L., Peng, B., Umar, M.I., Chan, C.-Y., Sahakyan, A.B., Le, M.T.N., Kwok, C.K. Structural Analysis Reveals Formation and Role of RNA G-Quadruplex Structures in Human Mature MicroRNAs. Chem Comm. 54, 10878-10881 (2018). https://doi.org/10.1039/c8cc04635b
21. Kwok, CK., Marsico, G., Balasubramanian, S. Detecting RNA G-quadruplexes (rG4s) in the Transcriptome. Cold Spring Harb Perspect Biol. 10:a032284 (2018). https://doi.org/10.1101/cshperspect.a032284
20. Ding, Y., Kwok, CK. Emergence of Vascular Plants. Nature Plants 4, 325–326 (2018). https://doi.org/10.1038/s41477-018-0159-0
2017
19. Kwok, CK., Merrick, C.J. G-Quadruplexes: Prediction, Characterization, and Biological Application. Trends Biotechnol. 35, 997–1013 (2017). https://doi.org/10.1016/j.tibtech.2017.06.012
18. Norris, M., Kwok, CK., Cheema J., Hartley M., Morris R.J., Aviran S., Ding, Y. FoldAtlas: A Repository for Genome-Wide RNA Structure Probing Data. Bioinformatics. 33, 306-308 (2017). https://doi.org/10.1093/bioinformatics/btw611
18. Norris, M., Kwok, CK., Cheema J., Hartley M., Morris R.J., Aviran S., Ding, Y. FoldAtlas: A Repository for Genome-Wide RNA Structure Probing Data. Bioinformatics. 33, 306-308 (2017). https://doi.org/10.1093/bioinformatics/btw611
2016
17. Kwok, CK., Dawn of the In Vivo RNA Structuome and Interactome. Biochem Soc. Trans. 44, 1395-1410 (2016). https://doi.org/10.1042/bst20160075
16. Kwok, CK., Marsico, G., Sahakyan, A., Chambers V.S., Balasubramanian, S. rG4-Seq Reveals Widespread Formation of G-Quadruplex Structures in the Human Transcriptome. Nat. Methods. 13, 841-844 (2016). https://doi.org/10.1038/nmeth.3965
15. Kwok, CK., Sahakyan, A., Balasubramanian, S. Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA. Angew. Chem. Int. Ed. 55, 8958-8961 (2016). https://doi.org/10.1002/anie.201603562
14. Sherlock, M.E., Rumble, C., Kwok, CK., Breffke, J., Maroncelli, M., & Bevilacqua, P.C. Steady-State and Time-Resolved Studies into the Origin of the Intrinsic Fluorescence of G-Quadruplexes. J. Phy. Chem. B 120, 5146-5158. (2016). https://doi.org/10.1021/acs.jpcb.6b03790
16. Kwok, CK., Marsico, G., Sahakyan, A., Chambers V.S., Balasubramanian, S. rG4-Seq Reveals Widespread Formation of G-Quadruplex Structures in the Human Transcriptome. Nat. Methods. 13, 841-844 (2016). https://doi.org/10.1038/nmeth.3965
15. Kwok, CK., Sahakyan, A., Balasubramanian, S. Structural Analysis using SHALiPE to Reveal RNA G-Quadruplex Formation in Human Precursor MicroRNA. Angew. Chem. Int. Ed. 55, 8958-8961 (2016). https://doi.org/10.1002/anie.201603562
14. Sherlock, M.E., Rumble, C., Kwok, CK., Breffke, J., Maroncelli, M., & Bevilacqua, P.C. Steady-State and Time-Resolved Studies into the Origin of the Intrinsic Fluorescence of G-Quadruplexes. J. Phy. Chem. B 120, 5146-5158. (2016). https://doi.org/10.1021/acs.jpcb.6b03790
2015
13. Crenshaw, E., Leung, B.P., Kwok, CK., Olson, K., Sebastian, N.P., Ansaloni, S., Schweitzer-Stenner, R., Akins, M.P., Bevilacqua, P.C., & Saunders, A.J. Amyloid Precursor Protein Translation is Regulated by a 3’UTR Guanine Quadruplex. PloS One. 10(11): e0143160. (2015). https://doi.org/10.1371/journal.pone.0143160
12. Ding, Y., Kwok, CK., Tang, Y., Bevilacqua, P.C., & Assmann, S.M. Structure-Seq: Genome-Wide Profiling of In Vivo RNA Structure at Single Nucleotide Resolution. Nat. Protoc. 10, 1050-1066 (2015). https://doi.org/10.1038/nprot.2015.064
11. Tang, Y., Bouvier, E., Kwok, CK., Ding, Y., Nekrutenko, A., Bevilacqua, P.C., & Assmann, S.M. StructureFold: Genome-Wide RNA Secondary Structure Mapping and Reconstruction In Vivo. Bioinformatics. 31, 2668-2675 (2015). https://doi.org/10.1093/bioinformatics/btv213
10. Kwok, CK., & Balasubramanian, S. Targeted Detection of G-Quadruplexes in Cellular RNAs. Angew. Chem. Int. Ed. 54, 6751-6754 (2015). (Selected as Hot Paper.) https://doi.org/10.1002/anie.201500891
9. Kwok, CK., Tang, Y., Assmann, S.M., & Bevilacqua, P.C. The RNA Structurome: Transcriptome-Wide Structure Probing using Next-Gen Sequencing. Trends Biochem. Sci. 40, 221-232 (2015). (Featured on the cover) https://doi.org/10.1016/j.tibs.2015.02.005
8. Kwok, CK., Ding, Y., Shahid, S., Assmann, S.M., & Bevilacqua, P.C. A Stable RNA G-Quadruplex within the 5’UTR of Arabidopsis Thaliana ATR mRNA Inhibits Translation. Biochem. J. 467, 91-102 (2015). (Featured in HFSP website) https://doi.org/10.1042/bj20141063
12. Ding, Y., Kwok, CK., Tang, Y., Bevilacqua, P.C., & Assmann, S.M. Structure-Seq: Genome-Wide Profiling of In Vivo RNA Structure at Single Nucleotide Resolution. Nat. Protoc. 10, 1050-1066 (2015). https://doi.org/10.1038/nprot.2015.064
11. Tang, Y., Bouvier, E., Kwok, CK., Ding, Y., Nekrutenko, A., Bevilacqua, P.C., & Assmann, S.M. StructureFold: Genome-Wide RNA Secondary Structure Mapping and Reconstruction In Vivo. Bioinformatics. 31, 2668-2675 (2015). https://doi.org/10.1093/bioinformatics/btv213
10. Kwok, CK., & Balasubramanian, S. Targeted Detection of G-Quadruplexes in Cellular RNAs. Angew. Chem. Int. Ed. 54, 6751-6754 (2015). (Selected as Hot Paper.) https://doi.org/10.1002/anie.201500891
9. Kwok, CK., Tang, Y., Assmann, S.M., & Bevilacqua, P.C. The RNA Structurome: Transcriptome-Wide Structure Probing using Next-Gen Sequencing. Trends Biochem. Sci. 40, 221-232 (2015). (Featured on the cover) https://doi.org/10.1016/j.tibs.2015.02.005
8. Kwok, CK., Ding, Y., Shahid, S., Assmann, S.M., & Bevilacqua, P.C. A Stable RNA G-Quadruplex within the 5’UTR of Arabidopsis Thaliana ATR mRNA Inhibits Translation. Biochem. J. 467, 91-102 (2015). (Featured in HFSP website) https://doi.org/10.1042/bj20141063
2014
7. Ding, Y., Tang, Y., Kwok, CK., Zhang, Y., Bevilacqua, P.C. Assmann, S.M. In vivo Genome-Wide Profiling of RNA Secondary Structures Reveal Novel Regulatory Features. Nature. 505, 696-700 (2014). (Featured on the cover, F1000 site http://f1000.com/prime/718185620, Nature 505, 621-622 (2014), Nat. Meth.11, 11 (2014) and Nat. Chem. Biol. 10, 87 (2014).) https://doi.org/10.1038/nature12756
2013
6. Kwok, CK., Ding, Y., Tang, Y., Assmann, S.M., Bevilacqua, P.C. Determination of in vivo RNA Structure in Low-Abundance Transcripts. Nat. Commun. 4, 2971 (2013). (Featured in Nat. Meth.11, 11 (2014).) https://doi.org/10.1038/ncomms3971
5. Kwok, CK., Lam, SL. NMR Proton Chemical Shift Prediction of T∙T Mismatches in B-DNA Duplexes. J. Magn. Reson. 234, 184-189 (2013). https://doi.org/10.1016/j.jmr.2013.06.022
4. Kwok, CK., Sherlock, M.E. & Bevilacqua, P.C. Effect of Loop Sequence and Loop Length on the Intrinsic Fluorescence of G-Quadruplexes. Biochemistry 52, 3019-3021 (2013). https://doi.org/10.1021/bi400139e
3. Kwok, CK., Ding, Y., Sherlock, M.E., Assmann, S.M. & Bevilacqua, P.C. A Hybridization-Based Approach for Quantitative and Low-Bias Single-Stranded DNA Ligation. Anal. Biochem. 435, 181-186 (2013). Featured on the cover. https://doi.org/10.1016/j.ab.2013.01.008
2. Kwok, CK., Sherlock, M.E. & Bevilacqua, P.C. Decrease in RNA Folding Cooperativity by Deliberate Population of Intermediates in RNA G-Quadruplexes. Angew. Chem., Int. Ed. 52, 683-686 (2013). (Featured in F1000 site. http://f1000.com/prime/717970147.) https://doi.org/10.1002/anie.201206475
2011
1. He, G., Kwok, CK. & Lam, SL. Preferential Base Pairing Modes of T.T Mismatches. FEBS Lett. 585, 3953-3958 (2011). https://doi.org/10.1016/j.febslet.2011.10.044