Exploring the Chemistry and Biology of Nucleic Acids
PhDs and Postdocs wanted for exciting i) G-quadruplex, ii) RNA, and iii) aptamer projects!
Email ([email protected]) with CV and research background if interested.
Email ([email protected]) with CV and research background if interested.
What our lab studies: - G-quadruplex Structure and Function - RNA Biology and Gene Regulation - Aptamer Development and Application Funding sources:
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Recent publications: Liu, Y., Shi, Y., Wang, S., Liu, S., Shang, M., Zhao, B., Liu, H., Yang, C., Wang, F., Kwok, C. K., Wang, H. Hook-Like DNAzyme-Activated Autocatalytic Biosensor for the Universal Detection of Pathogenic Bacteria. Anal. Chem. (2024) Zhang, K., Nie, Q., Lau, C. K., Kwok, C. K. Rational Design of L-RNA Aptamer-Peptide Conjugate for Efficient Cell Uptake and G-quadruplex-Mediated Gene Control. Angewandte Chemie. 136 (9), e202310798 (2024) Ji, D., Yuan, J., Chen, S., Tan, J., Kwok, C. K. Selective targeting of parallel G-quadruplex structure using L-RNA aptamer. Nucleic Acids Research. 51, 11439–11452 (2023) Mou, X., Kwok, C. K. Peptides Selected by G4-mRNA Display-Seq Enable RNA G-Quadruplex Recognition and Gene Regulation. JACS. 145, 18693−18697 (2023) Lyu, K., Kwok, C. K. RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays. Methods in Enzymology. 691, 63-80 (2023) Lyu, K., Kwok, C. K. A G-quadruplex structure in microRNA interferes with messenger RNA recognition and controls gene expression. ChemComm. 59, 8230 - 8233 (2023). Ji, D., Feng, H., Liew, S. W., Kwok, C. K. Modified nucleic acid aptamers: development, characterization, and biological applications. Trends in Biotechnology. 41(11), P1360-P1384 (2023). |
Recent lab news: Jun 2024: Congrats to Dr. Kwok on receiving RNA Society Early Career Award! May 2024: Congrats to Danyang on awarding Travel Awards for XXV IRT in Tokyo 2024! Mar 2024: Congrats to Kaixin on awarding the Outstanding Research Thesis Award 2023! Feb 2024: Congrats to Jesslyn on awarding HKSAR Government Scholarship 2023/2024! Feb 2024: Congrats to Caroline and Kun on awarding the RNA Society Research Presentation Fellowship! Jan 2024: Paper published in Angewandte Chemie. Congrats to Kun! Oct 2023: Paper published in Nucleic Acids Research. Congrats to Danyang! Aug 2023: Congrats to Sally on winning Outstanding Academic Performance Award (OAPA)! Aug 2023: Paper published in JACS. Congrats to Xi! Jun 2023: Paper published in Methods in Enzymology. Congrats to Kaixin! Jun 2023: CSCI Excellent Paper Award for Research Students. Congrats to Danyang, Sally and Caroline! |